Sibutramine (generic name: Sibutramine hydrochloride; trade name Reductil, Reduxade, and Ectiva in Europe and other countries, Meridia in the USA) is a once-daily prescription medication for weight loss and weight maintenance.
Sibutramine should be used as part of a comprehensive weight management program supervised by your doctor that includes a reduced calorie diet and appropriate physical activity.
Sibutramine is approved by the FDA for use by overweight patients with a body mass index (BMI) of 30+.
The recommended starting dose of Sibutramine is 10 mg administered once daily with or without food. If there is inadequate weight loss, the dose may be titrated after four weeks to a total of 15 mg once daily. The 5 mg dose should be reserved for patients who do not tolerate the 10 mg dose. Blood pressure and heart rate changes should be taken into account when making decisions regarding dose titration. Doses above 15 mg daily are not recommended. In most of the clinical trials, Sibutramine was given in the morning.
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